Lipogenesis: The Link between Acetyl-CoA and Fatty Acid Synthesis

Production of excessive amounts of acetyl CoA molecules leads to the synthesis of ____.

fatty acids only

The production of excessive amounts of acetyl-CoA molecules can lead to the synthesis of fatty acids. Acetyl-CoA is a precursor for fatty acid synthesis, and when there is an abundance of acetyl-CoA in the cell, the enzymatic machinery responsible for fatty acid synthesis can be activated. This process is called lipogenesis, and it occurs mainly in the liver, adipose tissue, and lactating mammary gland. The fatty acids synthesized from excess acetyl-CoA can either be stored within the cell as triglycerides or released into circulation to be used as an energy source by other tissues. It is worth noting that the production of acetyl-CoA can also occur through the oxidation of fatty acids.

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