Fatty Acid Synthesis: An Insight into Lipogenesis and its Energy Demands

Fatty acid synthesis begins with a preparatory step in which ___ is transferred from ___ to the ___. However, it cannot pass through the membrane, so it is transported as ___, which is cleaved to ___ to ___.

acetyl coAmitochondriacytoplasmcitrateacetyl CoAoxaloacetate

Fatty acid synthesis begins with a preparatory step in which acetyl-CoA is transferred from the mitochondria to the cytosol. However, it cannot pass through the membrane, so it is transported as citrate, which is cleaved to yield acetyl-CoA and oxaloacetate by the enzyme ATP-citrate lyase. Acetyl-CoA is then used in the process of fatty acid synthesis, which involves a series of enzymatic reactions that ultimately lead to the production of palmitate, a 16-carbon saturated fatty acid. This process is also known as lipogenesis and is an anabolic pathway that requires energy and reducing equivalents in the form of NADPH.

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