Which of the following is the major type of hemolysis characteristic of the majority of cases of HS?
Extravascular hemolysis
The major type of hemolysis characteristic of the majority of cases of HS (Hereditary Spherocytosis) is extravascular hemolysis. This occurs in the spleen and liver, where the abnormal spherocytes are recognized as abnormal and selectively removed by macrophages. This results in the destruction of these cells, leading to anemia. However, intravascular hemolysis can also occasionally occur in HS, particularly during times of infection or other stressors.
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