The membrane attack complex is made from
C5b, C6, C7, C8, and C9.
The membrane attack complex (MAC) is a complex of complement proteins that forms a pore in the membrane of target cells, causing lysis and cell death. It is made up of several complement proteins, including C5b, C6, C7, C8, and multiple copies of C9.
The process of MAC formation begins when the complement protein C5 is activated by a protease and cleaved into two fragments, C5a and C5b. C5b then binds to other complement proteins, including C6, C7, C8, and multiple copies of C9, to form a ring-shaped structure that inserts into the target cell membrane.
Once the MAC is inserted into the target cell membrane, it disrupts the membrane’s integrity and creates a pore that allows the influx and efflux of ions and molecules, ultimately leading to cell lysis and death.
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