The M2 ion channel blocking agent, amantadine, prevents what step of the viral life cycle?a. Translationb. Uncoatingc. Release of the nascent virus from the host celld. Assembly of new viral particles
b. Uncoating
The M2 ion channel blocking agent, amantadine, prevents the uncoating step of the viral life cycle. Influenza A virus enters the host cell through endocytosis and subsequently undergoes uncoating, where the viral RNA genome is released into the host cell. The viral M2 ion channel protein is critical for this process, as it allows for the acidification of the viral particle and the subsequent release of the viral genome. Amantadine blocks this process by inhibiting the activity of the M2 protein, which prevents the acidification of the viral particle and subsequently prevents the release of the viral genome into the host cell. As a result, the virus is unable to replicate and propagate.
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