Which patient would be most at risk for adverse reactions, when administered a highly protein bound medication? A. a 45 y/o malnourished maleB. an 80 y/o female on aspirin C. a 16 y/o with a rib fracture D. a 30 y/o pregnant woman
A.
B. an 80 y/o female on aspirin would be most at risk for adverse reactions when administered a highly protein-bound medication.
Highly protein-bound medications can displace other protein-bound drugs, leading to higher free drug concentrations and risk of toxicity. Aspirin is known to displace certain drugs from protein binding sites, so an 80-year-old female taking aspirin may already have a higher concentration of free drug in her system and be at a higher risk for adverse reactions if administered a highly protein-bound medication.
The other patients listed do not have any specific factors that suggest they would be at higher risk for adverse reactions with protein-bound medication administration.
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