Proinsulin is an 84 residue polypeptide with six cysteines. How many different disulfide combinations are possible?
To determine the number of different disulfide combinations possible in proinsulin, we need to consider the number of ways in which the six cysteine residues can form disulfide bonds.
In proinsulin, there are six cysteine residues present, denoted as C1, C2, C3, C4, C5, and C6. Each cysteine residue has the potential to form a disulfide bond with any other cysteine residue. Let’s analyze the possibilities:
1. Disulfide bond between C1 and C2: This is one possible combination
2. Disulfide bond between C1 and C3: This is another possible combination
3. Disulfide bond between C1 and C4: Again, this is another possible combination
4. Disulfide bond between C1 and C5: Yet another possible combination
5. Disulfide bond between C1 and C6: One more possible combination
6. Disulfide bond between C2 and C3: This is another valid combination
7. Disulfide bond between C2 and C4: Another combination
8. Disulfide bond between C2 and C5: Another combination
9. Disulfide bond between C2 and C6: Another combination
10. Disulfide bond between C3 and C4: Another combination
11. Disulfide bond between C3 and C5: Another combination
12. Disulfide bond between C3 and C6: Another combination
13. Disulfide bond between C4 and C5: Another combination
14. Disulfide bond between C4 and C6: Another combination
15. Disulfide bond between C5 and C6: Another combination
So, in total, there are 15 different disulfide combinations possible in proinsulin
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