The Role of the Liver in Filtration and Metabolism of Blood

How much percentage of substance does liver take in one pass?

In order to answer this question accurately, it is important to clarify which substance you are referring to. The liver is responsible for metabolizing a wide range of substances, including drugs, toxins, hormones, and nutrients.

One important process carried out by the liver is the filtration of blood through the hepatic portal system. This system collects blood from organs in the abdominal region, such as the intestines and spleen, and delivers it to the liver for processing. During this filtration process, the liver is able to extract and metabolize substances present in the blood.

The percentage of a substance that is metabolized by the liver in one pass, typically referred to as the hepatic extraction ratio, varies depending on the substance itself. Some substances undergo extensive hepatic metabolism, where a large proportion is metabolized by the liver before it can reach the systemic circulation. This can be the case for many drugs, leading to a phenomenon known as the first-pass metabolism.

However, there is no specific or fixed percentage for the hepatic extraction ratio, as it varies greatly between substances. It can range from very low values, where only a small fraction of a substance is metabolized, to almost complete extraction, where the majority is metabolized before leaving the liver. Examples of substances with high hepatic extraction ratios include propranolol, lidocaine, and morphine.

Therefore, without specifying the substance in question, it is not possible to provide an exact percentage for the amount of substance metabolized by the liver in one pass.

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