Why Haemophilia is Considered Unviable in Later Stages of Life

Why is haemophilia unviable in later stages of life?

Haemophilia is a genetic disorder that impairs the body’s ability to clot blood properly. It is caused by a deficiency or malfunction of certain proteins called clotting factors, specifically factors VIII or IX. This deficiency can lead to prolonged bleeding, even with minor injuries.

While haemophilia can pose challenges throughout a person’s life, it is generally considered more severe and potentially life-threatening in the earlier stages of life. Here are a few reasons why haemophilia is considered unviable in later stages of life:

1. Increased risk of joint damage: Over time, repeated bleeding episodes in the joints can cause significant damage, leading to chronic pain, limited movement, and even permanent disability. This is especially true for weight-bearing joints such as the knees and ankles. The accumulation of joint damage can greatly impact a person’s quality of life and mobility as they age.

2. Development of inhibitors: Some individuals with haemophilia may develop inhibitors, which are antibodies that neutralize the clotting factor replacement therapy they receive. Inhibitors can make it more challenging to control bleeding effectively and increase the risk of severe bleeding episodes. The development of inhibitors tends to be more common in the early stages of life but can also occur later on.

3. Impact on overall health: Haemophilia can affect various aspects of a person’s health. The need for frequent medical interventions, such as injections of clotting factor concentrates or surgeries to address bleeding or joint damage, can have long-term consequences. Complications like infections from treatment procedures or complications related to prolonged immobility can become more problematic as a person gets older or has other age-related health issues.

4. Age-related comorbidities: As individuals with haemophilia age, they may develop other health conditions like cardiovascular diseases, arthritis, or diabetes. These comorbidities can further complicate their overall health management, potentially making it more challenging to treat or control bleeding episodes effectively.

5. Social and mental health aspects: Living with a chronic condition like haemophilia can have emotional and social implications. As individuals age, they may face additional challenges related to employment, financial stability, and relationship dynamics. Coping with these aspects can be more complex as they navigate the physical limitations and potential comorbidities associated with haemophilia.

It is important to note that advancements in medical treatments and management strategies have significantly improved the outcomes and quality of life for individuals with haemophilia, regardless of age. However, it remains a complex and potentially life-altering condition that requires ongoing medical care and support.

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